The world’s first centre dedicated to studying and providing lifesaving innovations to children injured by
explosive weapons has been launched.
Children are seven times more likely to die from blast injuries than adults. They tend to experience
different types of injuries than adults and require specialist care that accounts for their physiology and
growth. However, research on the best ways to treat child-specific blast injuries lags far behind research
for injured adults.
To address those needs, Imperial College London and Save the Children have today launched the Centre
for Paediatric Blast Injury Studies at Imperial’s White City campus. The Centre brings together medics, engineers, pain specialists, operational humanitarians and prosthetics and rehabilitation experts who are already driving new research and innovations to meet the clinical needs of children with blast injuries.
“As more and more children today live in conflict zones, we need child-specific, translational research that looks at everything from the initial emergency response, to treatments, to prosthetics and development into adulthood.”
Professor Anthony Bull
Department of Bioengineering
The team will initially focus on addressing the lack of prosthetics for musculoskeletal and extremity
injuries in Ukraine, where four children per day are injured or killed and where mines and unexploded
ordnance threaten the lives and limbs of over two million children.
Centre director Professor Anthony Bull, of Imperial’s Department of Bioengineering, said: “As more and
more children today live in conflict zones, we need child-specific, translational research that looks at
everything from the initial emergency response, to treatments, to prosthetics and development into
adulthood. This new Centre will address an unmet need: treating children with blast injuries in a research-led, highly translational way to help them become healthy adults.”
Save the Children UK CEO Gwen Hines said: “For tens of thousands of children in Ukraine, war has
become a part of everyday life. Bombs rain from the sky and explosive devices now litter the ground close
to where they live and play.
“Tragically, there has never been a more pressing need for the knowledge and tools to better protect
children and care for them when they are hurt by these weapons of war. This new Centre is the next
phase in a ground-breaking collaboration; not just between Save the Children and Imperial but with
partners and allies on the ground in conflict zones from Yemen to Colombia, Afghanistan to Ukraine.”
Professor Hugh Brady, President of Imperial College London, said: “At Imperial College London, we are
driven by a commitment to making a difference in the world through our research. The harrowing impact of blast injuries on children in conflict zones is a powerful illustration of why this matters.
“Some of the greatest advances in healthcare come from research that spans disciplines. Imperial’s
vibrant interdisciplinary research culture, and our world-leading expertise in blast injuries, makes us
ideally placed to find solutions to this urgent global crisis. We are proud to partner with Save the Children to ensure our research has an impact where it is needed most.”
Unique unmet needs
Latest data revealed in 2021 that one in six children globally – 449 million children – lived in a conflict
zone. That figure will rise dramatically once the Ukraine conflict is considered. These children are at huge risk of injury and death from explosive weapons.
The risks loom even after conflicts finish: children are 50 per cent more likely to suffer blast injuries after fighting ends, as many of their injuries happen when they go outside to play again and pick up unexploded devices.
Professor Hugh Brady
President of Imperial College London
After a blast, children tend to suffer more internal damage than adults, as their underdeveloped skulls
and muscles offer less protection to the brain, lungs, and organs.
Like Imperial’s pioneering adult-focused Centre for Blast Injury Studies, the new Centre will translate
research into direct applications that address children’s clinical needs.
Although informed by the work in adults, the Centre will take a new approach driven by the needs of
children – a patient group with a more complex set of challenges because of their developing physiology
and ongoing growth.
Professor Bull said: “Children’s needs after blast injury are very different from those of adults. Their
treatment and rehabilitation must consider their unique physiology and future growth to allow them to
both heal and flourish. The new Centre will bring together the best minds in this field to drive better
treatment and care for child victims of blast injuries across the globe.”
Researchers at the new Centre are using motion capture technology to analyse the movements of people
using prosthetic limbs in detail and see how prosthetics can be improved. They can then quickly 3D print
new prototypes and conduct detailed tests to see how the prosthetics perform when faced with the
specific forces and strains the prosthetic will endure, so that new designs can be further refined.
The Centre also has facilities that simulate the effects of different types of blast, to study the fundamental
science behind blasts’ effects on how bones grow and how soft tissues heal.
Imperial PhD candidate Caitlin Edgar said: “We are already developing low-cost age-appropriate
prosthetics for children with limb amputation that consider growth and physiological development in
conflict affected areas. We will expand our research to the mechanical effects of blasts on the growth
mechanisms in bones, and the effects of pain and stress on trauma and healing.”
Strategic approach
The Centre will address the most important questions that are not being answered elsewhere. It will use
the initial funding from Save the Children to support new four-year PhD studentships to understand the
biomechanics of blast on the child, emergency medical needs, rehabilitation, and surgical and rehabilitation technology.
Professor Anthony Bull
Department of Bioengineering
As a hub of expertise, researchers from across disciplines will come together and use new knowledge to
influence policy and improve the lives of children affected by physical and psychological conflict trauma.
Imperial’s partnership with Save the Children is already addressing challenges faced by medics treating
children with blast injuries across the globe, including in resource-limited settings.
One such example is the Paediatric Blast Injury Field Manual, which helps medics in conflict zones treat
children quickly across the continuum of care. Already translated into six languages, the manual is being
used in twelve conflict zones including Ukraine, Syria, Yemen, and Afghanistan.
Speakers at the launch, hosted by Save the Children Ambassador Natasha Kaplinsky, included Professor Bull, Gwen Hines, Director of the University of Bath’s Centre for Pain Research Professor Christopher
Eccleston, Dr Andriy Dvorakevych PhD, leading paediatric surgeon at Lviv City Children’s Clinical
Hospital in Ukraine and Imperial PhD candidates Caitlin Edgar and Claudia Ghidini.