The FRAXA Research Foundation, which supports work aimed at finding a specific treatment for fragile Xsyndrome, has awarded Yuan-Chen Tsai, a postdoctoral fellow in UCI’s Department of Anatomy &
Neurobiology, a two-year, $100,000 grant to advance her studies. The genetic neurological disorder is
the most common inherited cause of autism as well as mild to severe intellectual disability and occurs
when a single gene mutates in the X chromosome, preventing proper brain development. Currently
working in the lab of Momoko Watanabe, assistant professor of anatomy & neurobiology, Tsai seeks to build human brain organoids – laboratory-grown brain tissues – that more closely model how fragile X alters gene activity in the human brain. “Our new system will be a valuable tool for improving our
understanding of the condition and provide a powerful testing platform, especially for preclinical drug
trials,” she said.